Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6274180 | 1.00 | THRB (0.42) | THRBMMP13RAB9ANPC1MAPT | |
| SCHEMBL6272560 | 0.91 | THRB (0.45) | THRBMMP13RAB9ANPC1MAPT | |
| SCHEMBL6278229 | 0.79 | CD74 (0.33) | THRBRAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL6273142 | 0.76 | SNCA (0.39) | RAB9ANPC1MAPTALDH1A1KDM4E | |
| SCHEMBL6273143 | 0.76 | SNCA (0.39) | RAB9ANPC1MAPTALDH1A1KDM4E | |
| SCHEMBL6274709 | 0.67 | MAPT (0.46) | MAPTSMN1; SMN2MAOB | |
| SCHEMBL6275956 | 0.65 | NPC1 (0.46) | RAB9ANPC1MAPTSMN1; SMN2HPGD | |
| SCHEMBL6275960 | 0.65 | NPC1 (0.46) | RAB9ANPC1MAPTSMN1; SMN2HPGD | |
| SCHEMBL6281046 | 0.62 | MAOB (0.33) | MAOB | |
| SCHEMBL1058756 | 0.61 | NPC1 (0.52) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005116010-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK FROSST CANADA LTD. (CA) | 2005-12-08 | — | — | WO | disclosed |