Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5697144 | 0.87 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL5697245 | 0.80 | MAPT (0.45) | SMN1; SMN2ALDH1A1MAPTRAB9ANPSR1 | |
| SCHEMBL5697075 | 0.80 | KDM6B (0.51) | SMN1; SMN2ALDH1A1MAPTRAB9APOLB | |
| SCHEMBL5697273 | 0.75 | GAA (0.46) | SMN1; SMN2ALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL5922862 | 0.71 | NPC1 (0.53) | MAPTRAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL22411030 | 0.70 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1MAPTRAB9ANPSR1 | |
| SCHEMBL9370863 | 0.70 | ALDH1A1 (0.88) | SMN1; SMN2ALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL6171613 | 0.70 | RAB9A (1.00) | SMN1; SMN2ALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL6273198 | 0.69 | HDAC3 (0.54) | SMN1; SMN2ALDH1A1MAPTRAB9AKDM4E | |
| SCHEMBL30034264 | 0.68 | SMN1; SMN2 (0.88) | SMN1; SMN2ALDH1A1MAPTRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1587516-A1 | AMIDE AND ESTER MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004064842-A1 | AMIDE AND ESTER MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-08-05 | — | — | WO | disclosed |