Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 6/20 | 0.52 |
| ▸ | TTBK2 | Q6IQ55 | 6/20 | 0.52 |
| ▸ | CDC7 | O00311 | 2/20 | 0.52 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.52 |
| ▸ | RHEB | Q15382 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AKT2 | P31751 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191691 | 0.78 | CDC7 (0.61) | TTBK1TTBK2CDC7DBF4MAPT | |
| SCHEMBL6424878 | 0.77 | MAPT (0.46) | TTBK1TTBK2CDC7DBF4RHEB | |
| SCHEMBL13885309 | 0.71 | JAK2 (0.61) | TTBK1TTBK2JAK2AXLPRKCI | |
| SCHEMBL6661474 | 0.70 | TRPA1 (0.52) | TTBK1TTBK2CDC7DBF4NOTUM | |
| SCHEMBL26784728 | 0.70 | TTBK1 (0.49) | TTBK1TTBK2CDC7DBF4MAPT | |
| SCHEMBL192920 | 0.69 | CDC7 (1.00) | TTBK1TTBK2CDC7DBF4MAPT | |
| SCHEMBL102201 | 0.68 | TTBK1 (0.54) | TTBK1TTBK2JAK2AXLPRKCI | |
| SCHEMBL6260636 | 0.68 | TRPA1 (0.64) | TTBK1TTBK2RHEBJAK2AXL | |
| SCHEMBL23702468 | 0.67 | RHEB (1.00) | RHEBMAPT | |
| SCHEMBL17954541 | 0.67 | CDC7 (0.63) | TTBK1TTBK2CDC7DBF4NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239806-A1 | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases | AMBIT BIOSCIENCES CORPORATION | 2005-10-27 | — | — | US | disclosed |
| WO-2005069865-A2 | PYRROLOPYRIMIDINE DERIVATIVES AND ANALOGS AND THEIR USE IN THE TREATMENT AND PREVENTION OF DISEASES | AMBIT BIOSCIENCES CORPORATION (US) | 2005-08-04 | — | — | WO | disclosed |
| US-20050165029-A1 | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases | AMBIT BIOSCIENCES CORPORATION | 2005-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165029-A1 | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases | PRKDC, PRKCA, PRKACA | TTBK1 356/4885TTBK2 391/4885CDC7 318/4885 |
| US-20050239806-A1 | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases | PRKDC, PRKCA, PRKACA | TTBK1 356/4885TTBK2 391/4885CDC7 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.