Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 6/20 | 0.39 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6274667 | 0.87 | BCHE (0.36) | CCR3TP53MDM2BCHE | |
| SCHEMBL6275762 | 0.85 | CCR3 (0.35) | CCR3BCHE | |
| SCHEMBL6095983 | 0.84 | CXCR3 (0.42) | CXCR3CCR5TP53MDM2CHRM1 | |
| SCHEMBL6097442 | 0.84 | CXCR3 (0.42) | CXCR3CCR5TP53MDM2CHRM1 | |
| SCHEMBL8312834 | 0.84 | CCR5 (0.40) | CCR5CCR3TP53MDM2 | |
| SCHEMBL6096740 | 0.84 | CCR5 (0.40) | CCR5CCR3TP53MDM2 | |
| SCHEMBL6274732 | 0.84 | CCR3 (0.34) | CCR3BCHEALDH1A1 | |
| SCHEMBL6096743 | 0.84 | CCR5 (0.40) | CCR5CCR3TP53MDM2 | |
| SCHEMBL6272381 | 0.83 | CCR3 (0.34) | CCR3BCHEALDH1A1 | |
| SCHEMBL8311127 | 0.78 | DRD4 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605941-A1 | SUBSTITUTED PIPERIDINES AS NOVEL MDM2-p53 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004080460-A1 | SUBSTITUTED PIPERIDINES AS NOVEL MDM2-p53 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-23 | — | — | WO | disclosed |