Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6268462 | 0.98 | SMN1; SMN2 (0.53) | SMN1; SMN2TPSAB1RAB9ANPC1HSD17B10 | |
| SCHEMBL25143234 | 0.95 | SMN1; SMN2 (0.53) | SMN1; SMN2TPSAB1RAB9ANPC1HSD17B10 | |
| SCHEMBL12569423 | 0.90 | SMN1; SMN2 (0.62) | SMN1; SMN2TPSAB1RAB9ANPC1HSD17B10 | |
| SCHEMBL4407874 | 0.88 | HSD17B10 (0.62) | SMN1; SMN2TPSAB1RAB9ANPC1HSD17B10 | |
| SCHEMBL10261559 | 0.86 | CASP3 (0.52) | SMN1; SMN2TPSAB1RAB9ANPC1HSD17B10 | |
| SCHEMBL8193282 | 0.83 | SMN1; SMN2 (0.61) | SMN1; SMN2TPSAB1RAB9ANPC1HSD17B10 | |
| SCHEMBL22926235 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANPC1HSD17B10MAPT | |
| SCHEMBL13273315 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9ANPC1HSD17B10MAPT | |
| SCHEMBL8342618 | 0.82 | NPC1 (0.53) | SMN1; SMN2RAB9ANPC1GAAPCSK9 | |
| SCHEMBL20613119 | 0.81 | HSD17B10 (0.57) | SMN1; SMN2RAB9ANPC1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606272-A1 | 3-(1-3-(1,3-BENZOTHIAZOL-6-YL)PROPYLCARBAMOYL CYCLOALKYL)PROPANOIC ACID DERIVATIVES AS NEP INHIBITORS | Pfizer Limited (GB) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004080985-A1 | 3-(1-[3-(1,3-BENZOTHIAZOL-6-YL)PROPYLCARBAMOYL]CYCLOALKYL)PROPANOIC ACID DERIVATIVES AS NEP INHIBITORS | PFIZER LIMITED (GB) | 2004-09-23 | — | — | WO | disclosed |
| WO-2004080985-A1 | 3-(1-[3-(1,3-BENZOTHIAZOL-6-YL)PROPYLCARBAMOYL]CYCLOALKYL)PROPANOIC ACID DERIVATIVES AS NEP INHIBITORS | PFIZER LIMITED (GB) | 2004-09-23 | — | — | WO | disclosed |