Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | AGXT | P21549 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6274725 | 0.88 | MAOB (0.47) | MAOBMEN1LMNACYP1A2HSP90AA1 | |
| SCHEMBL6274225 | 0.88 | ORAI1 (0.51) | MAOBMEN1LMNACYP1A2MAPT | |
| SCHEMBL4160507 | 0.84 | MAOB (0.52) | MAOBMEN1LMNACYP1A2HSP90AA1 | |
| SCHEMBL31500322 | 0.80 | MAPT (0.50) | MAOBMEN1LMNAMAPTKMT2A | |
| SCHEMBL2513277 | 0.77 | ALDH1A1 (0.55) | MAOBMEN1LMNACYP1A2HSP90AA1 | |
| SCHEMBL2514148 | 0.76 | APP (0.49) | MAOBMEN1LMNACYP1A2HSP90AA1 | |
| SCHEMBL1414014 | 0.74 | ALDH1A1 (0.53) | MAOBMEN1LMNACYP1A2HSP90AA1 | |
| SCHEMBL2389960 | 0.74 | ERN1 (0.55) | LMNACYP1A2MAPTCYP2C19TDP1 | |
| SCHEMBL1806215 | 0.74 | ERN1 (0.47) | MEN1LMNACYP1A2MAPTCYP2C19 | |
| SCHEMBL3120118 | 0.73 | PTGER2 (0.49) | THRATHRBRAB9AHTR1AMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005116010-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK FROSST CANADA LTD. (CA) | 2005-12-08 | — | — | WO | disclosed |