Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2513277 | 0.94 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTKMT2AHTT | |
| SCHEMBL4160507 | 0.89 | MAOB (0.52) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL2514148 | 0.84 | APP (0.49) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL2462874 | 0.84 | KMT2A (0.51) | ALDH1A1LMNAMAPTKMT2AHTT | |
| SCHEMBL1414062 | 0.83 | HTR1A (0.55) | ALDH1A1MAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL1413931 | 0.83 | MAPT (0.56) | ALDH1A1LMNAMAPTKMT2AHTT | |
| SCHEMBL2511877 | 0.83 | LMNA (0.42) | ALDH1A1LMNAMAPTKMT2AHTT | |
| SCHEMBL2515097 | 0.80 | APP (0.46) | ALDH1A1LMNAMAPTKMT2AHTT | |
| SCHEMBL2511985 | 0.80 | MAOB (0.44) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL2463869 | 0.80 | ALDH1A1 (0.43) | ALDH1A1LMNAMAPTKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994189-B2 | Dihydropyridine derivatives | N.V. ORGANON (NL) | 2011-08-09 | — | — | US | disclosed |
| EP-1879866-B1 | DIHYDROPYRIDINE DERIVATIVES | ORGANON NV (NL) | 2011-03-16 | — | — | EP | disclosed |
| US-20090215773-A1 | DIHYDROPYRIDINE DERIVATIVES | N.V.ORGANON (NL) | 2009-08-27 | — | — | US | disclosed |
| EP-1879866-A1 | DIHYDROPYRIDINE DERIVATIVES | N.V. Organon (NL) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006117023-A1 | DIHYDROPYRIDINE DERIVATIVES | N.V. ORGANON (NL) | 2006-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215773-A1 | DIHYDROPYRIDINE DERIVATIVES | CATSPER1, ODC1, ADH1C | ALDH1A1 124/4885LMNA 3311/4885MAPT 4079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.