Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 8/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.46 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627458 | 1.00 | FYN (0.48) | FYNPIK3CAHASPINKCNH2KIT | |
| SCHEMBL628259 | 0.87 | DPP4 (0.38) | FYNPIK3CAKCNH2DPP4DPP7 | |
| SCHEMBL628257 | 0.87 | DPP4 (0.38) | FYNPIK3CAKCNH2DPP4DPP7 | |
| SCHEMBL628258 | 0.87 | DPP4 (0.38) | FYNPIK3CAKCNH2DPP4DPP7 | |
| SCHEMBL627457 | 0.86 | DPP4 (0.40) | FYNPIK3CAKCNH2DPP4DPP7 | |
| SCHEMBL627441 | 0.81 | FYN (0.63) | FYNPIK3CAHASPIN | |
| SCHEMBL627439 | 0.81 | FYN (0.63) | FYNPIK3CAHASPIN | |
| SCHEMBL625300 | 0.80 | PIK3CA (0.51) | FYNPIK3CAHASPIN | |
| SCHEMBL626206 | 0.80 | PIK3CA (0.53) | FYNPIK3CAHASPIN | |
| SCHEMBL627396 | 0.79 | PIK3CA (0.53) | FYNPIK3CAHASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |