SCHEMBL6274601

SCHEMBL6274601

Cc1cccc(C)c1OC(N)CC(C)C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN4A P35499 11/20 0.52
SCN5A Q14524 3/20 0.52
MAOA P21397 3/20 0.52
LMNA P02545 2/20 0.52
SCN1A P35498 2/20 0.52
SCN9A Q15858 2/20 0.52
CYP1A2 P05177 2/20 0.52
CYP3A4 P08684 2/20 0.52
CYP2D6 P10635 2/20 0.52
NFKB1 P19838 2/20 0.52
TSHR P16473 2/20 0.52
SCN8A Q9UQD0 2/20 0.52
HTR2A P28223 2/20 0.52
CYP2C9 P11712 1/20 0.52
KCNK3 O14649 1/20 0.52
CACNA1F O60840 1/20 0.52
KCNK2 O95069 1/20 0.52
GBA1 P04062 1/20 0.52
SLC6A4 P31645 1/20 0.52
HTR2B P41595 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6272675 0.80 SCN4A (0.50) SCN4ASCN5AMAOALMNASCN1A
SCHEMBL9201474 0.77 SCN4A (0.55) SCN4ASCN5AMAOALMNASCN1A
SCHEMBL28060152 0.74 SCN4A (0.53) SCN4ASCN5AMAOALMNASCN1A
SCHEMBL19668682 0.73 SCN4A (0.51) SCN4ASCN5AMAOALMNASCN1A
SCHEMBL5591554 0.72 SCN4A (0.56) SCN4ASCN5AMAOALMNASCN1A
SCHEMBL104735 0.72 SCN4A (0.48) SCN4ASCN5AMAOALMNASCN1A
SCHEMBL19668685 0.70 SCN4A (0.53) SCN4ASCN5AMAOALMNASCN1A
SCHEMBL11580891 0.69 SCN4A (0.45) SCN4ASCN5AMAOALMNASCN1A
SCHEMBL9198060 0.69 SCN4A (0.53) SCN4ASCN5AMAOALMNASCN1A
SCHEMBL23804880 0.69 SCN4A (0.45) SCN4ASCN5AMAOALMNASCN1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1365757-B1 Use of xylyloxy alkyl amines for treating tinnitus ISOMEX LTD (GB) 2005-12-28 EP claimed
US-20040116535-A1 Use ISOMEX LIMITED (GB) 2004-06-17 US claimed
EP-1365757-A1 NEW USE Isomex Limited (GB) 2003-12-03 EP claimed
WO-2002062328-A1 NEW USE ISOMEX LIMITED (GB) 2002-08-15 WO claimed