Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6274948 | 0.83 | KMT2A (0.60) | AGTR1KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL1960956 | 0.79 | KMT2A (0.45) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL15651673 | 0.78 | KMT2A (0.44) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL4481965 | 0.77 | KMT2A (0.52) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL27291196 | 0.75 | ALDH1A1 (0.41) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL1815323 | 0.75 | POLB (0.50) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL4823228 | 0.74 | PSEN1 (0.53) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL23525646 | 0.73 | ALDH1A1 (0.40) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL16078881 | 0.73 | ALDH1A1 (0.40) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL1816952 | 0.73 | TXNRD1 (0.50) | KMT2AMEN1MAPTALDH1A1CRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592690-A1 | HETEROCYCLYL-3-SULFONYLAZAINDOLE OR -AZAINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004074286-A1 | HETEROCYCLYL-3-SULFONYLAZAINDOLE OR -AZAINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2004-09-02 | — | — | WO | disclosed |