Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3178615 | 0.86 | HDAC8 (0.43) | GRM2KDM4EAGTR2ALDH1A1HRH3 | |
| SCHEMBL3178603 | 0.77 | HDAC8 (0.43) | GRM2ALDH1A1HRH3SCN9A | |
| SCHEMBL13481738 | 0.73 | STS (0.42) | GRM2ALDH1A1HRH3SCN9A | |
| SCHEMBL3163185 | 0.73 | FFAR1 (0.55) | KDM4EALDH1A1TP53TSHRHRH3 | |
| SCHEMBL3181096 | 0.73 | RXRA (0.43) | GRM2KDM4ERXRARXRBRXRG | |
| SCHEMBL13481643 | 0.73 | RXRA (0.43) | GRM2KDM4ERXRARXRBRXRG | |
| SCHEMBL5332291 | 0.73 | GRM2 (0.48) | GRM2KDM4ERXRARXRBRXRG | |
| SCHEMBL1815343 | 0.71 | FFAR1 (0.42) | GRM2KDM4EAGTR2 | |
| SCHEMBL1815689 | 0.71 | FFAR1 (0.42) | GRM2KDM4EAGTR2 | |
| SCHEMBL23163612 | 0.71 | HRH3 (0.47) | GRM2KDM4EALDH1A1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558246-A1 | PROLINE DERIVATIVES HAVING AFFINITY FOR THE CALCIUM CHANNEL ALPHA-2-DELTA SUBUNIT | Pfizer Limited (GB) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004039367-A1 | PROLINE DERIVATIVES HAVING AFFINITY FOR THE CALCIUM CHANNEL ALPHA-2-DELTA SUBUNIT | PFIZER LIMITED (GN) | 2004-05-13 | — | — | WO | disclosed |