Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 4/20 | 0.67 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.67 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.67 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ezogabine SCHEMBL4054750 | 0.81 | KCNQ2 (1.00) | KCNQ2KCNQ3KCNQ4KCNQ5HSD17B10 | |
| Ezogabine SCHEMBL20835 | 0.81 | KCNQ2 (1.00) | KCNQ2KCNQ3KCNQ4KCNQ5HSD17B10 | |
| Ezogabine SCHEMBL29359156 | 0.81 | KCNQ2 (1.00) | KCNQ2KCNQ3KCNQ4KCNQ5HSD17B10 | |
| Ezogabine SCHEMBL15357224 | 0.81 | KCNQ2 (1.00) | KCNQ2KCNQ3KCNQ4KCNQ5HSD17B10 | |
| Ezogabine SCHEMBL154715 | 0.80 | KCNQ2 (0.98) | KCNQ2KCNQ3KCNQ4KCNQ5HSD17B10 | |
| Ezogabine SCHEMBL155918 | 0.80 | KCNQ2 (0.98) | KCNQ2KCNQ3KCNQ4KCNQ5HSD17B10 | |
| SCHEMBL1651597 | 0.79 | KCNQ3 (0.74) | KCNQ2KCNQ3KCNQ4KCNQ5HSD17B10 | |
| Ezogabine SCHEMBL15539530 | 0.78 | KCNQ2 (0.94) | KCNQ2KCNQ3KCNQ4KCNQ5HSD17B10 | |
| SCHEMBL16625703 | 0.78 | KCNQ3 (0.57) | KCNQ2KCNQ3KCNQ4KCNQ5HSD17B10 | |
| SCHEMBL1226537 | 0.76 | KCNQ3 (0.54) | KCNQ2KCNQ3KCNQ4KCNQ5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326597-B1 | USE OF KCNQ POTASSIUM CHANNEL AGONISTS FOR THE MANUFACTURE OF A MEDICAMENT FOR MODULATING BLADDER FUNCTION | WYETH CORP (US) | 2005-12-28 | — | — | EP | disclosed |