Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 3/20 | 0.54 |
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | CES1 | P23141 | 3/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10828102 | 1.00 | MAPT (0.56) | MAPTRAB9ACASP3SENP8SENP7 | |
| SCHEMBL17182759 | 0.79 | CES2 (0.57) | MAPTRAB9ACASP3SENP8SENP7 | |
| SCHEMBL17182758 | 0.79 | CES2 (0.57) | MAPTRAB9ACASP3SENP8SENP7 | |
| SCHEMBL17182764 | 0.79 | TSHR (0.44) | MAPTRAB9ACASP3SENP8SENP7 | |
| SCHEMBL17182763 | 0.79 | TSHR (0.44) | MAPTRAB9ACASP3SENP8SENP7 | |
| SCHEMBL282530 | 0.78 | MAPT (0.50) | MAPTRAB9ACASP3SENP8SENP7 | |
| SCHEMBL10376096 | 0.76 | MAPT (0.52) | MAPTRAB9ACASP3SENP8SENP7 | |
| SCHEMBL27680737 | 0.75 | MAPT (0.50) | MAPTRAB9ACASP3SENP8SENP7 | |
| SCHEMBL592051 | 0.75 | F2 (0.55) | MAPTRAB9ACASP3SENP8SENP7 | |
| SCHEMBL592052 | 0.75 | F2 (0.55) | MAPTRAB9ACASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005106025-A1 | METABOLIC TEST | PML APPLICATIONS LTD. (GB) | 2005-11-10 | — | — | WO | disclosed |
| EP-0138750-B1 | PROCESS FOR THE PRODUCTION OF SUBSTITUTED BENZIMIDAZOLES | CIBA-GEIGY AG (CH) | 1987-09-09 | — | — | EP | disclosed |
| EP-0138760-B1 | PROCESS FOR THE PREPARATION OF N-SUBSTITUTED ORTHO-PHENYLENE-DIAMINES | CIBA-GEIGY AG (CH) | 1986-12-10 | — | — | EP | disclosed |
| EP-0138760-A1 | Process for the preparation of N-substituted ortho-phenylene-diamines | CIBA-GEIGY AG (CH) | 1985-04-24 | — | — | EP | disclosed |
| EP-0138750-A1 | Process for the production of substituted benzimidazoles | CIBA-GEIGY AG (CH) | 1985-04-24 | — | — | EP | disclosed |