Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 17/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5838233 | 0.91 | P2RX7 (0.56) | P2RX7 | |
| SCHEMBL5837770 | 0.86 | P2RX7 (0.73) | P2RX7ABCB11 | |
| SCHEMBL6276507 | 0.81 | P2RX7 (0.54) | P2RX7ABCB11 | |
| SCHEMBL1412881 | 0.80 | P2RX7 (0.73) | P2RX7ABCB11SPR | |
| SCHEMBL5839002 | 0.79 | P2RX7 (0.73) | P2RX7 | |
| SCHEMBL5838136 | 0.79 | P2RX7 (0.73) | P2RX7 | |
| SCHEMBL5837470 | 0.76 | P2RX7 (0.59) | P2RX7SPR | |
| SCHEMBL1412923 | 0.75 | P2RX7 (0.76) | P2RX7ABCB11SPR | |
| SCHEMBL1415261 | 0.74 | P2RX7 (0.74) | P2RX7ABCB11SPR | |
| SCHEMBL5838546 | 0.74 | P2RX7 (0.57) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581507-A1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | Pfizer Products Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058731-A1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2004-07-15 | — | — | WO | disclosed |