Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 17/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5838248 | 0.89 | HSD17B1 (0.50) | P2RX7HSD17B1HSD17B2CNR2 | |
| SCHEMBL5837770 | 0.84 | P2RX7 (0.73) | P2RX7ABCB11KDM4EMEN1ALDH1A1 | |
| SCHEMBL6276504 | 0.81 | P2RX7 (0.56) | P2RX7ABCB11 | |
| SCHEMBL1412884 | 0.78 | P2RX7 (0.62) | P2RX7ABCB11HSD17B1HSD17B2 | |
| SCHEMBL5839014 | 0.77 | P2RX7 (0.49) | P2RX7CNR2 | |
| SCHEMBL5838143 | 0.77 | P2RX7 (0.49) | P2RX7CNR2 | |
| SCHEMBL5837478 | 0.74 | HSD17B1 (0.51) | P2RX7HSD17B1HSD17B2CNR2 | |
| SCHEMBL1412926 | 0.73 | P2RX7 (0.64) | P2RX7ABCB11MEN1ALDH1A1KMT2A | |
| SCHEMBL1415262 | 0.72 | P2RX7 (0.62) | P2RX7ABCB11MEN1ALDH1A1KMT2A | |
| SCHEMBL5838554 | 0.72 | HSD17B1 (0.49) | P2RX7HSD17B1HSD17B2CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581507-A1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | Pfizer Products Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058731-A1 | BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2004-07-15 | — | — | WO | disclosed |