Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL28326280 | 0.70 | GLA (0.37) | AGTR1AGTR2 | |
| SCHEMBL5484884 | 0.67 | AGTR1 (0.36) | AGTR1AGTR2HCAR2PPARG | |
| SCHEMBL3109908 | 0.67 | HCAR2 (0.43) | HCAR2 | |
| SCHEMBL15894461 | 0.67 | RARB (0.43) | HCAR2 | |
| SCHEMBL5701035 | 0.66 | HCAR2 (0.44) | HCAR2PPARG | |
| SCHEMBL4886946 | 0.64 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL20504181 | 0.60 | NPSR1 (0.43) | HCAR2 | |
| SCHEMBL3862291 | 0.60 | HCAR2 (0.40) | HCAR2 | |
| SCHEMBL948543 | 0.60 | HCAR2 (0.46) | HCAR2PPARG | |
| SCHEMBL9642982 | 0.60 | GPR35 (0.48) | HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005066137-A1 | 2,5-DIARYL-1H-IMIDAZOLE-4-CARBOXAMIDES AS NEUROKININ-3 RECEPTOR MODULATORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES | NEUROGEN CORPORATION (US) | 2005-07-21 | — | — | WO | disclosed |