Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 11/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | F7 | P08709 | 3/20 | 0.39 |
| ▸ | F3 | P13726 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627714 | 1.00 | PSEN1 (0.60) | PSEN1ALDH1A1F7F3PPARG | |
| SCHEMBL627713 | 1.00 | PSEN1 (0.60) | PSEN1ALDH1A1F7F3PPARG | |
| SCHEMBL13084619 | 0.97 | PSEN1 (0.62) | PSEN1ALDH1A1F7F3PPARG | |
| SCHEMBL634454 | 0.97 | PSEN1 (0.62) | PSEN1ALDH1A1F7F3PPARG | |
| SCHEMBL634455 | 0.97 | PSEN1 (0.62) | PSEN1ALDH1A1F7F3PPARG | |
| SCHEMBL13084634 | 0.97 | PSEN1 (0.62) | PSEN1ALDH1A1F7F3PPARG | |
| SCHEMBL628645 | 0.97 | PSEN1 (0.62) | PSEN1ALDH1A1F7F3PPARG | |
| SCHEMBL628647 | 0.97 | PSEN1 (0.62) | PSEN1ALDH1A1F7F3PPARG | |
| SCHEMBL13084717 | 0.97 | PSEN1 (0.62) | PSEN1ALDH1A1F7F3PPARG | |
| SCHEMBL628646 | 0.97 | PSEN1 (0.62) | PSEN1ALDH1A1F7F3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461362-B2 | Protein phosphatase 2A-activating agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-06-11 | — | — | US | disclosed |
| US-8362071-B2 | Antiadhesion agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-01-29 | — | — | US | disclosed |
| US-8362071-B2 | Antiadhesion agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-01-29 | — | — | US | disclosed |
| EP-2419414-A1 | PROTEIN PHOSPHATASE 2A-ACTIVATING AGENTS | The Ohio State University Research Foundation (US) | 2012-02-22 | — | — | EP | disclosed |
| US-20100267820-A1 | ANTIADHESION AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-10-21 | — | — | US | disclosed |
| US-20100267820-A1 | ANTIADHESION AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-10-21 | — | — | US | disclosed |
| US-20100267673-A1 | PROTEIN PHOSPHATASE 2A-ACTIVATING AGENTS | THE OHIO SATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-10-21 | — | — | US | disclosed |
| WO-2010121111-A1 | ANTIADHESION AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010120711-A1 | PROTEIN PHOSPHATASE 2A-ACTIVATING AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267673-A1 | PROTEIN PHOSPHATASE 2A-ACTIVATING AGENTS | PPP2CA, PPP2R2A, PPP2R1A | PSEN1 1965/4885ALDH1A1 400/4885F7 4480/4885 |
| US-20100267820-A1 | ANTIADHESION AGENTS | SELE, EPCAM, SELP | PSEN1 3830/4885ALDH1A1 45/4885F7 205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.