Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | TERT | O14746 | 6/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1355051 | 0.98 | ALDH1A1 (0.70) | ALDH1A1POLBKMT2ALMNAMEN1 | |
| SCHEMBL1356631 | 0.87 | TP53 (0.70) | ALDH1A1LMNAMAPTTERT | |
| SCHEMBL962893 | 0.85 | LMNA (0.74) | ALDH1A1POLBKMT2ALMNAALOX15 | |
| SCHEMBL2180527 | 0.85 | LMNA (0.54) | ALDH1A1POLBKMT2ALMNAMEN1 | |
| SCHEMBL3012622 | 0.84 | ALDH1A1 (1.00) | ALDH1A1POLBKMT2ALMNAMEN1 | |
| SCHEMBL22407734 | 0.84 | KDM4E (0.68) | ALDH1A1POLBKMT2ALMNAMEN1 | |
| SCHEMBL1355900 | 0.84 | KDM4E (0.68) | ALDH1A1POLBKMT2ALMNAMEN1 | |
| SCHEMBL6492893 | 0.83 | LMNA (0.56) | ALDH1A1POLBKMT2ALMNAMEN1 | |
| SCHEMBL1355565 | 0.83 | KDM4E (0.67) | ALDH1A1POLBKMT2ALMNAMEN1 | |
| SCHEMBL13149726 | 0.82 | KMT2A (0.97) | ALDH1A1POLBKMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836613-B1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2005-05-25 | — | — | EP | disclosed |
| US-5795977-A | Water soluble adenosine kinase inhibitors | METABASIS THERAPEUTICS, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| EP-0836613-A1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-22 | — | — | EP | disclosed |
| US-5726302-A | SUBSTITUTED 4-AMINO PYRROLO(2,3-D) PYRIMIDINE AND PYRAZOLO(3,4-D) PYRIMIDINE NUCLEOSIDE ANALOGS | GENSIA INC. (US) | 1998-03-10 | — | — | US | disclosed |
| WO-1996040707-A1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |