Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA2 | O43464 | 2/20 | 0.71 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.58 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3897920 | 1.00 | HTRA2 (0.71) | HTRA2INSRIGF1RPTPN12PTPN22 | |
| SCHEMBL3897914 | 1.00 | HTRA2 (0.71) | HTRA2INSRIGF1RPTPN12PTPN22 | |
| SCHEMBL3892423 | 0.92 | HTRA2 (0.61) | HTRA2INSRIGF1RPTPN12PTPN22 | |
| SCHEMBL3892418 | 0.92 | HTRA2 (0.61) | HTRA2INSRIGF1RPTPN12PTPN22 | |
| SCHEMBL7168872 | 0.92 | PTPN12 (0.72) | HTRA2INSRIGF1RPTPN12PTPN22 | |
| SCHEMBL6784929 | 0.92 | PTPN12 (0.72) | HTRA2INSRIGF1RPTPN12PTPN22 | |
| SCHEMBL8175997 | 0.90 | MAP3K5 (0.66) | HTRA2INSRIGF1RPTPN12PTPN22 | |
| SCHEMBL3900015 | 0.87 | HTRA2 (0.55) | HTRA2INSRIGF1RPTPN12PTPN22 | |
| SCHEMBL3900012 | 0.87 | HTRA2 (0.55) | HTRA2INSRIGF1RPTPN12PTPN22 | |
| SCHEMBL3896729 | 0.86 | MAPT (0.60) | HTRA2INSRIGF1RPTPN12PTPN22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005041951-A2 | RHODANINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | WO | claimed |