Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | TDO2 | P48775 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 4/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280820 | 0.88 | PTGS2 (0.70) | PTGS2MAPK14IDO1TDO2PTGS1 | |
| SCHEMBL6282411 | 0.85 | PTGS2 (0.57) | PTGS2MAPK14IDO1TDO2CDC7 | |
| SCHEMBL6286367 | 0.83 | PTGS2 (0.48) | PTGS2MAPK14IDO1TDO2CDC7 | |
| SCHEMBL6280438 | 0.83 | MAPK14 (0.59) | PTGS2MAPK14IDO1TDO2CDC7 | |
| SCHEMBL15688673 | 0.82 | PTGS2 (0.65) | PTGS2MAPK14PTGS1CDC7DBF4 | |
| SCHEMBL6503233 | 0.82 | PTGS2 (0.78) | PTGS2MAPK14PTGS1 | |
| SCHEMBL6286370 | 0.82 | MEN1 (0.50) | PTGS2MAPK14IDO1TDO2CDC7 | |
| SCHEMBL6280814 | 0.82 | MAPK14 (0.55) | PTGS2MAPK14IDO1TDO2CDC7 | |
| SCHEMBL15690382 | 0.80 | PTGS2 (0.50) | PTGS2MAPK14IDO1TDO2PTGS1 | |
| SCHEMBL6280962 | 0.80 | PTGS2 (0.48) | PTGS2MAPK14IDO1TDO2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | claimed |
| US-6962933-B1 | Method for inhibiting p38 MAP kinase or TNF-α production using a 1,3-thiazole | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-08 | — | — | US | disclosed |
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | disclosed |