Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | TDO2 | P48775 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 5/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6276676 | 0.86 | PTGS2 (0.64) | PTGS2KDM4EIDO1TDO2CDC7 | |
| SCHEMBL15690382 | 0.86 | PTGS2 (0.50) | PTGS2KDM4ELMNARAB9ASMN1; SMN2 | |
| SCHEMBL6286370 | 0.85 | MEN1 (0.50) | PTGS2KDM4ELMNARAB9ASMN1; SMN2 | |
| SCHEMBL6280962 | 0.83 | PTGS2 (0.48) | PTGS2KDM4ELMNARAB9ASMN1; SMN2 | |
| SCHEMBL6279375 | 0.83 | PTGS2 (0.54) | PTGS2KDM4ELMNARAB9ASMN1; SMN2 | |
| SCHEMBL6600796 | 0.82 | PTGS2 (0.49) | PTGS2KDM4ELMNARAB9ASMN1; SMN2 | |
| SCHEMBL6283249 | 0.82 | MAPK14 (0.54) | PTGS2IDO1TDO2CDC7DBF4 | |
| SCHEMBL6283027 | 0.81 | MAPK14 (0.50) | PTGS2KDM4ELMNARAB9AIDO1 | |
| SCHEMBL6505966 | 0.80 | PTGS2 (0.50) | PTGS2KDM4ELMNARAB9ASMN1; SMN2 | |
| SCHEMBL6575979 | 0.80 | PTGS2 (0.47) | PTGS2KDM4ELMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | claimed |
| US-6962933-B1 | Method for inhibiting p38 MAP kinase or TNF-α production using a 1,3-thiazole | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-08 | — | — | US | disclosed |
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | disclosed |