Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 13/20 | 0.42 |
| ▸ | NAALAD2 | Q9Y3Q0 | 4/20 | 0.41 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL627951 | 1.00 | TGFBR1 (0.46) | TGFBR1FOLH1NAALAD2RIMKLAMME | |
| SCHEMBL29166088 | 0.88 | TGFBR1 (0.43) | TGFBR1FOLH1NAALAD2RIMKLAMME | |
| SCHEMBL14865083 | 0.83 | TGFBR1 (0.33) | TGFBR1ALOX15 | |
| SCHEMBL387926 | 0.83 | TGFBR1 (0.46) | TGFBR1FOLH1NAALAD2RIMKLAMME | |
| SCHEMBL387925 | 0.83 | TGFBR1 (0.46) | TGFBR1FOLH1NAALAD2RIMKLAMME | |
| SCHEMBL627910 | 0.83 | TGFBR1 (0.64) | TGFBR1FOLH1NAALAD2MMEKDM4E | |
| SCHEMBL3448069 | 0.83 | TGFBR1 (0.64) | TGFBR1FOLH1NAALAD2MMEKDM4E | |
| SCHEMBL627909 | 0.83 | TGFBR1 (0.64) | TGFBR1FOLH1NAALAD2MMEKDM4E | |
| SCHEMBL524873 | 0.82 | FOLH1 (0.41) | TGFBR1FOLH1NAALAD2RIMKLAKDM4E | |
| SCHEMBL9152878 | 0.82 | FOLH1 (0.41) | TGFBR1FOLH1NAALAD2RIMKLAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109970749-A | The antiviral compound inhibitor of HCV NS5A | 吉利德制药有限责任公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-106432254-B | The antiviral compound inhibitor of HCV NS5A | 吉利德制药有限责任公司 | 2018-12-28 | — | — | CN | disclosed |
| CN-106432254-A | Antiviral compounds inhibitors of HVC NS5B | 吉利德制药有限责任公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-104487442-B | Antiviral Compound Inhibitors of HCV NS5A | 吉利德制药有限责任公司 | 2016-10-26 | — | — | CN | disclosed |
| US-9278922-B2 | Anti-viral compounds | ABBVIE INC. (US) | 2016-03-08 | — | — | US | disclosed |
| EP-2419404-B1 | ANTI-VIRAL COMPOUNDS | ABBVIE INC (US) | 2015-11-04 | — | — | EP | disclosed |
| CN-102459165-B | Antiviral compound | ABBVIE (US) | 2015-09-02 | — | — | CN | disclosed |
| EP-2640719-A2 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2012068234-A2 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-05-24 | — | — | WO | disclosed |
| EP-2419404-A1 | ANTI-VIRAL COMPOUNDS | Abbott Laboratories (US) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010120935-A1 | ANTI-VIRAL COMPOUNDS | ABBOTT LABORATORIES (US) | 2010-10-21 | — | — | WO | disclosed |
| US-20100267634-A1 | Anti-Viral Compounds | Abbott Labaoratories (US) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267634-A1 | Anti-Viral Compounds | HAVCR2, EIF2AK2, MAVS | TGFBR1 4637/4885FOLH1 4361/4885NAALAD2 1168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.