Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.46 |
| ▸ | CCND1 | P24385 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | CCND3 | P30281 | 4/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6283049 | 0.93 | CDK4 (0.47) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL5952412 | 0.81 | CHEK1 (0.52) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL5951902 | 0.79 | RET (0.48) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL5952470 | 0.79 | NPC1 (0.55) | CHEK1KDRKDM4EALDH1A1PDE10A | |
| SCHEMBL5951899 | 0.78 | ALOX5 (0.55) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL5952657 | 0.78 | NPC1 (0.50) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL5952326 | 0.78 | NMT1 (0.50) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL5952104 | 0.78 | NPC1 (0.52) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL5951585 | 0.77 | NPC1 (0.54) | CDK4CCNA2CCND1CDK2CCND3 | |
| SCHEMBL5953539 | 0.77 | HDAC6 (0.52) | CDK4CCNA2CCND1CDK2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897208-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | disclosed |