Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6283496 | 0.73 | ALDH1A1 (0.37) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL6287824 | 0.72 | SMN1; SMN2 (0.36) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL2265850 | 0.67 | SMN1; SMN2 (0.39) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL4913392 | 0.64 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL33804 | 0.63 | MAPT (0.55) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL4914514 | 0.63 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL6285815 | 0.62 | HPGD (0.36) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL1800736 | 0.62 | NPC1 (0.54) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL6259439 | 0.62 | MAPT (0.53) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA | |
| SCHEMBL13860397 | 0.62 | CDK8 (0.50) | ALDH1A1KDM4EHPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923929-B1 | KERATIN FIBRE DYE COMPOSITION CONTAINING PYRAZOLO-AZOLE COMPOUNDS, USE THEREOF AS OXIDATION AGENTS, AND DYEING METHOD; PYRAZOLOAZOLES | OREAL (FR) | 2004-05-12 | — | — | EP | claimed |
| US-20020152558-A1 | Compositions for dyeing keratinous fibers comprising pyrazoloazoles; their use in dyeing as oxidation base and dyeing process; and novel pyrazoloazoles | L'OREAL | 2002-10-24 | — | — | US | claimed |
| US-6379397-B2 | CAPABLE OF GENERATING INTENSE COLORINGS IN VARIED SHADES | L'OREAL S.A. (FR) | 2002-04-30 | — | — | US | claimed |
| US-6855827-B2 | Compositions for dyeing keratinous fibers comprising pyrazoloazoles; their use in dyeing as oxidation base and dyeing process; and novel pyrazoloazoles | L'ORÉAL (FR) | 2005-02-15 | — | — | US | disclosed |
| US-20020152558-A1 | Compositions for dyeing keratinous fibers comprising pyrazoloazoles; their use in dyeing as oxidation base and dyeing process; and novel pyrazoloazoles | L'OREAL | 2002-10-24 | — | — | US | disclosed |
| US-6379397-B2 | CAPABLE OF GENERATING INTENSE COLORINGS IN VARIED SHADES | L'OREAL S.A. (FR) | 2002-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020152558-A1 | Compositions for dyeing keratinous fibers comprising pyrazoloazoles; their use in dyeing as oxidation base and dyeing process; and novel pyrazoloazoles | KRT18, ZYX, TUBB3 | ALDH1A1 264/4885KDM4E 1907/4885HPGD 806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.