Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6281042 | 1.00 | LMNA (0.42) | LMNAHDAC1HDAC6MAPTMEN1 | |
| SCHEMBL6280467 | 0.93 | MAPT (0.42) | LMNAMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL6280457 | 0.93 | MAPT (0.42) | LMNAMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL4315347 | 0.87 | MAPT (0.48) | LMNAMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL3181213 | 0.86 | MAPT (0.49) | LMNAMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL4310071 | 0.86 | MAPT (0.43) | LMNAHDAC1HDAC6MAPTMEN1 | |
| SCHEMBL3351829 | 0.85 | KDM4E (0.44) | LMNAMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL1951779 | 0.84 | MAPT (0.51) | LMNAMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL1951777 | 0.84 | MAPT (0.51) | LMNAMAPTMEN1KMT2AMAPK1 | |
| SCHEMBL2749823 | 0.83 | MAPT (0.57) | LMNAMAPTMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894165-B2 | Imidazonaphthyridines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2005-05-17 | — | — | US | disclosed |
| US-20040204436-A1 | Imidazonaphthyridines | MEDICIS PHARMACEUTICAL CORPORATION | 2004-10-14 | — | — | US | disclosed |
| US-6699878-B2 | Imidazonaphthyridines | 3M INNOVATIVE PROPERTIES COMPANY | 2004-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204436-A1 | Imidazonaphthyridines | IFNG, IRF3, IFNAR1 | LMNA 3209/4885HDAC1 1650/4885HDAC6 1469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.