SCHEMBL628158

SCHEMBL628158

[CH2]CCC(O)(CC)CC

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3162189 0.85 FDPS (0.35)
SCHEMBL3167502 0.82
SCHEMBL3158437 0.80
SCHEMBL4892209 0.79 ALDH1A1 (0.38)
SCHEMBL1674824 0.78
SCHEMBL191751 0.76
SCHEMBL733313 0.75
Ammonia Solution, Strong SCHEMBL2471319 0.73 FDPS (0.39)
SCHEMBL628819 0.73
Water SCHEMBL26643057 0.73 FDPS (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180327354-A1 Unnatural Analogues of Calcitriol and Uses Thereof VIDASYM, LLC 2018-11-15 US claimed
EP-2419403-B1 VITAMIN D RECEPTOR AGONISTS AND USES THEREOF VIDASYM INC (US) 2016-09-07 EP claimed
CN-102482210-B Vitamin D receptor agonists and uses thereof VIDASYM LLC 2015-04-08 CN claimed
CN-102482210-A Vitamin d receptor agonists and uses thereof VIDASYM LLC 2012-05-30 CN claimed
US-20120115824-A1 Vitamin D Receptor Agonists and Uses Thereof VIDASYM, LLC (US) 2012-05-10 US claimed
EP-2419403-A1 VITAMIN D RECEPTOR AGONISTS AND USES THEREOF Vidasym, Llc (US) 2012-02-22 EP claimed
WO-2010120698-A1 VITAMIN D RECEPTOR AGONISTS AND USES THEREOF VIDASYM, LLC (US) 2010-10-21 WO claimed
US-20060074255-A1 3-Methyl-20-epi-vitamin D derivatives TAKAYAMA HIROAKI 2006-04-06 US claimed
US-20050119240-A1 1-methyl-20-epi-vitamin d derivative CHUGAI SEIYAKU KAABUSHIKI KAISHA (JP) 2005-06-02 US claimed
US-20050032754-A1 5,6-Trans-2-alkylvitamin D derivatives HIROAKI TAKAYAMA 2005-02-10 US claimed
US-20040030167-A1 3-Methyl-20-epi-vitamin d derivatives CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2004-02-12 US claimed
US-20030092687-A1 5,6-Trans-2-alkylvitamin d derivatives HIROAKI TAKAYAMA (JP) 2003-05-15 US claimed
EP-1310484-A1 1-METHYL-20-EPIVITAMIN D DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2003-05-14 EP claimed
EP-1284259-A1 5,6- i TRANS /i -2-ALKYLVITAMIN D DERIVATIVES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2003-02-19 EP claimed
CN-1398254-A Vitamin D derivatives having substituents at 2 alpha position CHUGAI PHARMACEUTICAL CO LTD (JP) 2003-02-19 CN claimed
US-20030022872-A1 Vitamin d derivatives having substituents at the 2 alpha-position TAKAYAMA, HIROAKI (JP) 2003-01-30 US claimed
EP-1260502-A1 VITAMIN D DERIVATIVES HAVING SUBSTITUENTS AT THE 2ALPHA-POSITION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2002-11-27 EP claimed
EP-1026155-A1 VITAMIN D DERIVATIVES AND PROCESS FOR PRODUCING THE SAME CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2000-08-09 EP claimed
US-5824811-A 22-Thiavitamin D3 derivatives CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1998-10-20 US claimed
EP-3901147-B1 ACYLAMINO BRIDGED HETEROCYCLIC COMPOUND, AND COMPOSITION AND APPLICATION THEREOF BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) 2023-11-22 EP disclosed
US-20230026425-A1 ACYLAMINO BRIDGED HETEROCYCLIC COMPOUND, AND COMPOSITION AND APPLICATION THEREOF BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) 2023-01-26 US disclosed
EP-3901147-A1 ACYLAMINO BRIDGED HETEROCYCLIC COMPOUND, AND COMPOSITION AND APPLICATION THEREOF Beijing Scitech-MQ Pharmaceuticals Limited (CN) 2021-10-27 EP disclosed
CN-113166116-A Amido bridged heterocyclic compound, and composition and application thereof 北京赛特明强医药科技有限公司 2021-07-23 CN disclosed
US-20180327354-A1 Unnatural Analogues of Calcitriol and Uses Thereof VIDASYM, LLC 2018-11-15 US disclosed
EP-2419403-B1 VITAMIN D RECEPTOR AGONISTS AND USES THEREOF VIDASYM INC (US) 2016-09-07 EP disclosed
CN-102482210-B Vitamin D receptor agonists and uses thereof VIDASYM LLC 2015-04-08 CN disclosed
CN-102482210-A Vitamin d receptor agonists and uses thereof VIDASYM LLC 2012-05-30 CN disclosed
US-20120115824-A1 Vitamin D Receptor Agonists and Uses Thereof VIDASYM, LLC (US) 2012-05-10 US disclosed
EP-2419403-A1 VITAMIN D RECEPTOR AGONISTS AND USES THEREOF Vidasym, Llc (US) 2012-02-22 EP disclosed
WO-2010120698-A1 VITAMIN D RECEPTOR AGONISTS AND USES THEREOF VIDASYM, LLC (US) 2010-10-21 WO disclosed
EP-1219599-B1 VITAMIN D DERIVATIVES HAVING SUBSTITUENTS AT THE 2 ALPHA-POSITION TAKAYAMA HIROAKI (JP) 2010-03-31 EP disclosed
US-20090124819-A1 2-SUBSTITUTED VITAMIN D DERIVATIVES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2009-05-14 US disclosed
EP-1466900-B1 2-SUBSTITUTED VITAMIN D DERIVATIVES TAKAYAMA HIROAKI (JP) 2009-01-14 EP disclosed
US-7465541-B1 Vitamin D3-responsive sequences located 5′-upstream of p27/kip 1 gene and methods of screening for pharmaceutical agents using the sequences TOSHIYUKI SAKAI (JP) 2008-12-16 US disclosed
US-7402688-B2 2,2-Di-substituted 1alpha,25-dihydroxy-19-norvitamin D derivative WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2008-07-22 US disclosed
EP-1103300-B1 ULTRAVIOLET IRRADIATION APPARATUS FOR PHOTOCHEMICAL REACTION AND METHOD FOR PREPARING VITAMIN D DERIVATIVE USING THE SAME CHUGAI PHARMACEUTICAL CO LTD (JP) 2007-01-03 EP disclosed
US-20060160779-A1 2,2-Di-substituted 1alpha,25-dihydroxy-19-norvitamin d derivative WISCONSIN ALUMNI RESEARCH FOUNDATION 2006-07-20 US disclosed
EP-0870503-B9 use of vitamin D derivatives for the manufacture of a medicament for treating MALIGNANT TUMOR METASTASIS CHUGAI PHARMACEUTICAL CO LTD (JP) 2006-06-28 EP disclosed
US-20060074255-A1 3-Methyl-20-epi-vitamin D derivatives TAKAYAMA HIROAKI 2006-04-06 US disclosed
EP-1559708-A1 2,2-DI-SUBSTITUTED 1a,25-DIHYDROXY-19-NORVITAMIN D DERIVATIVE Shimizu, Masato (JP) 2005-08-03 EP disclosed
US-20050131242-A1 2-substituted vitamin d derivatives CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2005-06-16 US disclosed
US-6902654-B2 Ultraviolet irradiation apparatus for photochemical reaction and preparation process of vitamin D derivative making use of the same CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2005-06-07 US disclosed
US-20050119240-A1 1-methyl-20-epi-vitamin d derivative CHUGAI SEIYAKU KAABUSHIKI KAISHA (JP) 2005-06-02 US disclosed
US-20050113349-A1 2-Alpha vitamin D derivatives having substituents HIROAKI TAKAYAMA (JP) 2005-05-26 US disclosed
US-6869940-B2 Malignant tumor metastasis inhibitors CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2005-03-22 US disclosed
EP-0870503-B1 use of vitamin D derivatives for the manufacture of a medicament for treating MALIGNANT TUMOR METASTASIS CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) 2005-03-16 EP disclosed
US-20050032754-A1 5,6-Trans-2-alkylvitamin D derivatives HIROAKI TAKAYAMA 2005-02-10 US disclosed
EP-1466900-A1 2-SUBSTITUTED VITAMIN D DERIVATIVES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2004-10-13 EP disclosed
US-20040108198-A1 Ultraviolet irradiation apparatus for photochemical reaction and preparation process of vitamin D derivative making use of the same CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2004-06-10 US disclosed
CN-1150973-C Ultraviolet irradiation device for photochemical reaction and method for producing vitamin D derivative using same ������ҩ��ʽ���� 2004-05-26 CN disclosed
US-20040030167-A1 3-Methyl-20-epi-vitamin d derivatives CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2004-02-12 US disclosed
EP-0972762-B1 Novel structural analogues of vitamin D THERAMEX (MC) 2003-10-01 EP disclosed
EP-0947504-B1 16-ENE-VITAMIN D DERIVATIVES CHUGAI PHARMACEUTICAL CO LTD (JP) 2003-09-03 EP disclosed
US-6566351-B1 Administering dihydroxyvitamin D3 derivative for inhibiting bone metastasis of malignant tumor in a patient in need of such inhibition and without treating the underlying cancer CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2003-05-20 US disclosed
US-20030092687-A1 5,6-Trans-2-alkylvitamin d derivatives HIROAKI TAKAYAMA (JP) 2003-05-15 US disclosed
EP-1310484-A1 1-METHYL-20-EPIVITAMIN D DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2003-05-14 EP disclosed
US-6555699-B2 Antitumor and antirheumatic agents, high binding affinity CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2003-04-29 US disclosed
US-6548715-B1 Which lacks the combined presence of the trans-fused ring; increased therapeutic potential; for cell proliferation; veterinary medicine LABORATOIRE THERAMEX S.A. (MC) 2003-04-15 US disclosed
EP-1284259-A1 5,6- i TRANS /i -2-ALKYLVITAMIN D DERIVATIVES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2003-02-19 EP disclosed
CN-1398254-A Vitamin D derivatives having substituents at 2 alpha position CHUGAI PHARMACEUTICAL CO LTD (JP) 2003-02-19 CN disclosed
US-20030022872-A1 Vitamin d derivatives having substituents at the 2 alpha-position TAKAYAMA, HIROAKI (JP) 2003-01-30 US disclosed
US-20020198182-A1 Malignant tumor metastasis inhibitors CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2002-12-26 US disclosed
US-20020193616-A1 16-ENE-VITAMIN D DERIVATIVES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2002-12-19 US disclosed
EP-1260502-A1 VITAMIN D DERIVATIVES HAVING SUBSTITUENTS AT THE 2ALPHA-POSITION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2002-11-27 EP disclosed
EP-0764443-B1 PRODUCTS FOR THE TREATMENT OF CACHEXIA ASSOCIATED WITH TUMORS CHUGAI PHARMACEUTICAL CO LTD (JP) 2002-08-14 EP disclosed
US-6433200-B1 ANTITUMOR AND ANTIRHEUMATIC AGENTS, HIGH BINDING AFINITY TO VITAMIN D RECEPTORS AND WEAK HYPERCALCEMIC ACTIVITY CHUGEI SEIYAKU KABUSHIKI KAISHA (JP) 2002-08-13 US disclosed
EP-1219599-A1 VITAMIN D DERIVATIVES HAVING SUBSTITUENTS AT THE 2 ALPHA-POSITION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2002-07-03 EP disclosed
CN-1341213-A Process for screening compound having affinity for vitamin D receptor CHUGEL SEIYAKU K K (JP) 2002-03-20 CN disclosed
US-20020032340-A1 16-ene-vitamin D derivatives CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2002-03-14 US disclosed
EP-1174424-A1 3-METHYLATED VITAMIN D DERIVATIVES CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2002-01-23 EP disclosed
US-6326503-B1 ANTITUMOR AGENTS CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2001-12-04 US disclosed
EP-1158297-A1 METHOD FOR SCREENING COMPOUND HAVING AFFINITY FOR VITAMIN D RECEPTOR CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2001-11-28 EP disclosed
CN-1307502-A Ultraviolet irradiation device for photochemical reaction and method for producing vitamin D derivative using same CHUGAI PHARMACEUTICAL CO LTD (JP) 2001-08-08 CN disclosed
EP-1103300-A1 ULTRAVIOLET IRRADIATION APPARATUS FOR PHOTOCHEMICAL REACTION AND METHOD FOR PREPARING VITAMIN D DERIVATIVE USING THE SAME CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2001-05-30 EP disclosed
US-6184398-B1 ANTITUMOR AGENTS AND TREATMENT OF RHEUMATIC CONDITIONS; HIGH BINDING ABILITY TO VITAMIN D RECEPTORS AND WEAK HYPERCALCEMIC ACTIVITY; E.G.,1,3-DIHYDROXY-20-3-HYDROXY-3-METHYLBUTYLTHIO)-9,10-SECOPREGNA -5,7,10(19),16-TETRAENE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2001-02-06 US disclosed
EP-0755922-B1 22-THIAVITAMIN D3 DERIVATIVE CHUGAI PHARMACEUTICAL CO LTD (JP) 2000-08-16 EP disclosed
EP-1026155-A1 VITAMIN D DERIVATIVES AND PROCESS FOR PRODUCING THE SAME CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2000-08-09 EP disclosed
EP-1021401-A1 CALCITRIOL DERIVATIVES AND THEIR USES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2000-07-26 EP disclosed
EP-0707566-B1 NOVEL STRUCTURAL ANALOGUES OF VITAMIN D THERAMEX (MC) 2000-04-12 EP disclosed
US-6017907-A Structural analogues of vitamin D LABORATOIRE THERAMEX S.A. (MC) 2000-01-25 US disclosed
EP-0972762-A2 Novel structural analogues of vitamin D LABORATOIRE THERAMEX (MC) 2000-01-19 EP disclosed
CN-1046502-C 22-thio vitamin D3Derivatives of the same CHUGAI PHARMACEUTICAL CO LTD (JP) 1999-11-17 CN disclosed
US-5977092-A Drug for curing/ameliorating concomitant syndrome of tumor CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1999-11-02 US disclosed
US-5976784-A DERIVATIVE WITH IN VIVO HYDROLYZABLE HYDROCARBYLOXYCARBONYL OR ACYL GROUPS FOR GRADUAL IN VIVO RELEASE OF BIOLOGICALLY ACTIVE VITAMIN D COMPOUND; TREATMENT OF OSTEOPOROSIS, PSORIASIS, RENAL OSTEODYSTROPHY, GLANDULAR AND BONE DISORDERS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1999-11-02 US disclosed
EP-0947504-A1 16-ENE-VITAMIN D DERIVATIVES Chugai Seiyaku Kabushiki Kaisha (JP) 1999-10-06 EP disclosed
US-5824811-A 22-Thiavitamin D3 derivatives CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1998-10-20 US disclosed
EP-0870503-A1 MALIGNANT TUMOR METASTASIS INHIBITORS Chugai Seiyaku Kabushiki Kaisha (JP) 1998-10-14 EP disclosed
CN-1148380-A 22-thiavitamin D3 derivative CHUGAI PHARMACEUTICAL CO LTD (JP) 1997-04-23 CN disclosed
WO-1997011053-A1 CALCITRIOL DERIVATIVES AND THEIR USES WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1997-03-27 WO disclosed
EP-0764443-A1 AMELIORANT OR REMEDY FOR PARANEOPLASTIC SYNDROME Chugai Seiyaku Kabushiki Kaisha (JP) 1997-03-26 EP disclosed
EP-0755922-A1 22-THIAVITAMIN D 3 DERIVATIVE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 1997-01-29 EP disclosed
EP-0707566-A1 NOVEL STRUCTURAL ANALOGUES OF VITAMIN D LABORATOIRE THERAMEX S.A. (MC) 1996-04-24 EP disclosed
WO-1995001960-A1 NOVEL STRUCTURAL ANALOGUES OF VITAMIN D LABORATOIRE THERAMEX S.A. (MC) 1995-01-19 WO disclosed
WO-1995001960-A1 NOVEL STRUCTURAL ANALOGUES OF VITAMIN D LABORATOIRE THERAMEX S.A. (MC) 1995-01-19 WO disclosed