Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 19/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.55 |
| ▸ | F2 | P00734 | 7/20 | 0.55 |
| ▸ | PLG | P00747 | 4/20 | 0.53 |
| ▸ | PROC | P04070 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6285012 | 0.87 | F10 (0.53) | F10PRSS1F2PLGPROC | |
| SCHEMBL6280049 | 0.85 | F10 (0.53) | F10PRSS1F2PLGPROC | |
| SCHEMBL6283261 | 0.85 | F10 (0.53) | F10PRSS1F2PLGPROC | |
| SCHEMBL7123099 | 0.84 | F10 (0.72) | F10PRSS1F2PLGPROC | |
| SCHEMBL6280036 | 0.84 | F10 (0.69) | F10PRSS1F2PLGPROC | |
| SCHEMBL7112916 | 0.82 | F10 (0.53) | F10PRSS1F2PLGPROC | |
| SCHEMBL6275783 | 0.82 | F10 (0.53) | F10PRSS1F2PLGPROC | |
| SCHEMBL6283268 | 0.81 | F10 (0.70) | F10PRSS1F2PLGPROC | |
| SCHEMBL6281579 | 0.81 | F10 (0.70) | F10PRSS1F2PLGPROC | |
| SCHEMBL6280320 | 0.81 | F10 (0.51) | F10PRSS1F2PLGPROC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855726-B1 | Quinolones as serine protease inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-15 | — | — | US | claimed |
| EP-1091955-A1 | QUINOLONES AS SERINE PROTEASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2001-04-18 | — | — | EP | claimed |
| WO-1999050263-A1 | QUINOLONES AS SERINE PROTEASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1999-10-07 | — | — | WO | claimed |
| US-6855726-B1 | Quinolones as serine protease inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-15 | — | — | US | disclosed |