Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.46 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6055173 | 0.80 | ATM (0.63) | IDO1TDO2KDM4ELMNAKMT2A | |
| SCHEMBL9185732 | 0.79 | ALDH1A1 (0.52) | KDM4ELMNAANO1ANO2L3MBTL1 | |
| SCHEMBL28037651 | 0.78 | MEN1 (0.47) | KDM4ELMNAL3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL2179155 | 0.78 | KDM4E (0.51) | KDM4EANO1ANO2L3MBTL1ALDH1A1 | |
| SCHEMBL7738208 | 0.78 | TAAR1 (0.48) | IDO1KDM4ELMNAANO1ANO2 | |
| SCHEMBL8102792 | 0.75 | CYP1A2 (0.73) | KDM4ELMNAL3MBTL1ALDH1A1CYP1A2 | |
| SCHEMBL10889471 | 0.75 | SMN1; SMN2 (0.64) | KDM4ELMNAANO1ANO2L3MBTL1 | |
| SCHEMBL8311153 | 0.75 | NQO1 (0.47) | KDM4ELMNAANO1ANO2ALDH1A1 | |
| SCHEMBL1176796 | 0.74 | ESRRA (0.51) | KDM4ELMNAL3MBTL1ALDH1A1NPSR1 | |
| SCHEMBL14544643 | 0.74 | MAPT (0.48) | KDM4ELMNAL3MBTL1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6930123-B2 | sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 2005-08-16 | — | — | US | disclosed |
| US-20040059130-A1 | Spla2 inhibitors | BEIGHT DOUGLAS WADE (US) | 2004-03-25 | — | — | US | disclosed |
| EP-1349832-A2 | SUBSTITUTED BENZOINDOLES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002050028-A2 | SUBSTITUTED BENZOINDOLES AS SPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040059130-A1 | Spla2 inhibitors | F2RL1, SPINT2, PLAAT2 | IDO1 2830/4885TDO2 1780/4885KDM4E 4225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.