Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.45 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9185732 | 0.90 | ALDH1A1 (0.52) | KDM4EALDH1A1NPSR1RXFP1NPC1 | |
| SCHEMBL14544643 | 0.85 | MAPT (0.48) | KDM4EALDH1A1NPSR1RXFP1MTNR1B | |
| SCHEMBL6820161 | 0.84 | LTA4H (0.55) | KDM4EALDH1A1NPSR1RXFP1NPC1 | |
| SCHEMBL6820163 | 0.84 | LTA4H (0.55) | KDM4EALDH1A1NPSR1RXFP1NPC1 | |
| SCHEMBL7715008 | 0.84 | LTA4H (0.55) | KDM4EALDH1A1NPSR1RXFP1NPC1 | |
| SCHEMBL14521459 | 0.82 | MAPT (0.46) | KDM4EALDH1A1NPSR1RXFP1NPC1 | |
| SCHEMBL7738208 | 0.78 | TAAR1 (0.48) | KDM4EALDH1A1NPSR1RXFP1NPC1 | |
| SCHEMBL6055173 | 0.78 | ATM (0.63) | KDM4ENPC1RAB9AMEN1KMT2A | |
| SCHEMBL6281901 | 0.78 | IDO1 (0.47) | KDM4EALDH1A1NPSR1RXFP1NPC1 | |
| Benzene SCHEMBL6822148 | 0.78 | MMP2 (0.47) | KDM4EALDH1A1NPSR1RXFP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050282872-A1 | Novel thyroid receptor ligands and method II | HANGELAND JON | 2005-12-22 | — | — | US | claimed |
| EP-2631238-A1 | Spirocyclic inhibitors of serine proteases for the treatment of hcv infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-28 | — | — | EP | disclosed |
| US-8440706-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-05-14 | — | — | US | disclosed |
| EP-1917269-B1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMA (US) | 2011-10-26 | — | — | EP | disclosed |
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | PRSS1, PRSS3, PRSS2 | KDM4E 2603/4885ALDH1A1 1374/4885NPSR1 1382/4885 |
| US-20050282872-A1 | Novel thyroid receptor ligands and method II | TSHR, THRB, THRA | KDM4E 3918/4885ALDH1A1 2107/4885NPSR1 100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.