Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1611509 | 0.86 | ALDH1A1 (0.69) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL14605919 | 0.85 | MEN1 (0.56) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL1493449 | 0.84 | POLB (0.68) | MEN1KMT2AMAPTPOLBLMNA | |
| SCHEMBL1702875 | 0.83 | TDP1 (0.69) | MEN1KMT2AMAPTPOLBLMNA | |
| SCHEMBL1611721 | 0.83 | LMNA (0.76) | MEN1KMT2APOLBLMNAALDH1A1 | |
| SCHEMBL1493311 | 0.80 | ALDH1A1 (0.76) | MEN1KMT2APOLBLMNAALDH1A1 | |
| SCHEMBL1610173 | 0.79 | POLB (0.76) | MEN1KMT2AMAPTPOLBLMNA | |
| SCHEMBL1611340 | 0.78 | POLB (0.59) | MEN1KMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL1612844 | 0.77 | POLB (0.73) | MEN1KMT2AMAPTPOLBLMNA | |
| SCHEMBL1493487 | 0.77 | ALDH1A1 (0.79) | MEN1KMT2AMAPTPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005115147-A2 | HIV REVERSE TRANSCRIPTASE INHIBITORS | MERCK & CO., INC. (US) | 2005-12-08 | — | — | WO | disclosed |