Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6282051 | 1.00 | KDR (0.34) | KDREGFRIGF1RSRCFLT4 | |
| SCHEMBL5250921 | 0.85 | KDR (0.36) | KDREGFRIGF1RSRCFLT4 | |
| SCHEMBL5250919 | 0.85 | KDR (0.36) | KDREGFRIGF1RSRCFLT4 | |
| SCHEMBL14493402 | 0.77 | EGFR (0.34) | KDREGFRIGF1RSRCFLT4 | |
| SCHEMBL6283631 | 0.76 | RET (0.35) | RAB9AKDM4EALDH1A1NPC1HPGD | |
| SCHEMBL6283634 | 0.76 | RET (0.35) | RAB9AKDM4EALDH1A1NPC1HPGD | |
| SCHEMBL5246902 | 0.74 | PTGS2 (0.42) | RAB9AKDM4EALDH1A1NPC1GAA | |
| SCHEMBL5246898 | 0.74 | PTGS2 (0.42) | RAB9AKDM4EALDH1A1NPC1GAA | |
| SCHEMBL5526396 | 0.70 | CHEK1 (0.39) | KDREGFRNPC1 | |
| SCHEMBL14493368 | 0.70 | CHEK1 (0.39) | KDREGFRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6891044-B2 | Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |