Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.32 |
| ▸ | RELA | Q04206 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6283634 | 1.00 | RET (0.35) | RETNPC1KDM4EALDH1A1RAB9A | |
| SCHEMBL6285089 | 0.82 | F2RL1 (0.34) | RETNPC1 | |
| SCHEMBL27615251 | 0.80 | CNR1 (0.37) | RETNPC1KDM4EALDH1A1MAPT | |
| SCHEMBL5248918 | 0.80 | KDR (0.35) | RETNPC1GRM4ALOX5APFEN1 | |
| SCHEMBL5248919 | 0.80 | KDR (0.35) | RETNPC1GRM4ALOX5APFEN1 | |
| SCHEMBL25170244 | 0.78 | ALOX5AP (0.35) | NPC1ALOX5APFEN1 | |
| SCHEMBL5512063 | 0.78 | NPC1 (0.36) | NPC1KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7511036 | 0.78 | NPC1 (0.36) | NPC1KDM4EALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL5514694 | 0.77 | NPC1 (0.33) | NPC1ALOX5APFEN1 | |
| SCHEMBL7507059 | 0.77 | NPC1 (0.33) | NPC1ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6891044-B2 | Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |