Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.70 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.46 |
| ▸ | CHRNG | P07510 | 4/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.46 |
| ▸ | CHRND | Q07001 | 4/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1731562 | 0.88 | PTPN1 (0.52) | PTPN1KLKB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL2184299 | 0.88 | PTPN1 (0.52) | PTPN1KLKB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1731564 | 0.88 | PTPN1 (0.52) | PTPN1KLKB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6282167 | 0.85 | PTPN1 (0.62) | PTPN1CHRNA1CHRNGCHRNB1CHRND | |
| SCHEMBL5893349 | 0.85 | PTPN1 (0.57) | PTPN1 | |
| SCHEMBL1732891 | 0.82 | PTPN1 (0.50) | PTPN1KLKB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL2186575 | 0.82 | PTPN1 (0.50) | PTPN1KLKB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1732660 | 0.82 | PTPN1 (0.50) | PTPN1KLKB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL5893008 | 0.82 | PTPN1 (1.00) | PTPN1CHRNA1CHRNGCHRNB1CHRND | |
| SCHEMBL6365920 | 0.82 | PTPN1 (1.00) | PTPN1CHRNA1CHRNGCHRNB1CHRND |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141596-B2 | Inhibitors of proteins that bind phosphorylated molecules | INCYTE CORPORATION (US) | 2006-11-28 | — | — | US | disclosed |
| US-20050272778-A1 | Inhibitors of proteins that bind phosphorylated molecules | INCYTE CORPORATION | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272778-A1 | Inhibitors of proteins that bind phosphorylated molecules | PPP3CA, PPP5C, PPM1A | PTPN1 133/4885CHRNA1 4619/4885CHRNG 4123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.