Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.39 |
| ▸ | CTSL | P07711 | 4/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | REN | P00797 | 9/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5954856 | 1.00 | CTSS (0.39) | CTSSCTSLCTSKRENALDH1A1 | |
| SCHEMBL5430907 | 0.91 | CTSS (0.39) | CTSSCTSLCTSKRENALDH1A1 | |
| Benzene SCHEMBL5954861 | 0.89 | CTSS (0.36) | CTSSCTSLCTSKRENALDH1A1 | |
| SCHEMBL5955869 | 0.89 | CTSS (0.42) | CTSSCTSLCTSKRENALDH1A1 | |
| SCHEMBL6078504 | 0.85 | CTSS (0.41) | CTSSCTSLCTSKRENPRSS1 | |
| SCHEMBL5955016 | 0.85 | REN (0.40) | CTSSCTSLCTSKREN | |
| SCHEMBL5955164 | 0.85 | REN (0.40) | CTSSCTSLCTSKREN | |
| SCHEMBL5418218 | 0.85 | REN (0.40) | CTSSCTSLCTSKREN | |
| SCHEMBL5955789 | 0.84 | CTSS (0.39) | CTSSCTSLCTSKRENPRSS1 | |
| SCHEMBL8360184 | 0.84 | CTSS (0.39) | CTSSCTSLCTSKRENPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515726-A1 | MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2005-03-23 | — | — | EP | disclosed |
| WO-2004002491-A1 | MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2004-01-08 | — | — | WO | disclosed |