Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280747 | 0.83 | KDM4E (0.45) | ALDH1A1KDM4EELANEHDAC6 | |
| SCHEMBL23397121 | 0.77 | KMT2A (0.46) | RAB9ANPC1TP53ALDH1A1KDM4E | |
| SCHEMBL18171819 | 0.77 | ALDH1A1 (0.56) | RAB9ANPC1TP53ALDH1A1KDM4E | |
| SCHEMBL2811174 | 0.75 | ALDH1A1 (0.49) | RAB9ANPC1TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL15982318 | 0.75 | ALDH1A1 (0.49) | RAB9ANPC1TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL28519312 | 0.75 | ALDH1A1 (0.49) | RAB9ANPC1TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL25422192 | 0.75 | ALDH1A1 (0.49) | RAB9ANPC1TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL12004770 | 0.75 | ALDH1A1 (0.49) | RAB9ANPC1TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL7641512 | 0.75 | MAPK14 (0.62) | — | |
| SCHEMBL15023570 | 0.74 | LMNA (0.47) | RAB9ANPC1TP53ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852744-B2 | Pyrrolidine derivatives and their use as chymase inhibitor | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2005-02-08 | — | — | US | disclosed |
| US-6835714-B1 | Heterocyclic compounds, intermediates thereof and elastase inhibitors | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2004-12-28 | — | — | US | disclosed |
| US-20040102384-A1 | Pyrrolidine derivatives and their use as chymase inhibitor | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2004-05-27 | — | — | US | disclosed |
| EP-1157998-B1 | HETEROCYCLIC COMPOUNDS, INTERMEDIATES THEREOF AND ELASTASE INHIBITORS | DAINIPPON PHARMACEUTICAL CO (JP) | 2004-02-11 | — | — | EP | disclosed |
| EP-1157998-A1 | HETEROCYCLIC COMPOUNDS, INTERMEDIATES THEREOF AND ELASTASE INHIBITORS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2001-11-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102384-A1 | Pyrrolidine derivatives and their use as chymase inhibitor | CMA1, CTRL, TPSD1 | RAB9A 1748/4885NPC1 1986/4885TP53 2331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.