Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL760516 | 0.76 | RAB9A (0.49) | POLBTSHRALDH1A1L3MBTL1HTT | |
| SCHEMBL2010247 | 0.72 | SMN1; SMN2 (0.69) | POLBTSHRALDH1A1HPGDHTT | |
| Hydrochloric Acid SCHEMBL3843750 | 0.70 | TSHR (0.53) | POLBTSHRALDH1A1L3MBTL1HPGD | |
| SCHEMBL7141238 | 0.70 | ALDH1A1 (0.60) | POLBTSHRALDH1A1L3MBTL1HPGD | |
| SCHEMBL7982548 | 0.69 | SMN1; SMN2 (0.64) | POLBTSHRALDH1A1L3MBTL1HPGD | |
| SCHEMBL24896765 | 0.69 | POLB (0.47) | POLBTSHRALDH1A1L3MBTL1HPGD | |
| SCHEMBL6224736 | 0.68 | HDAC1 (0.62) | POLBTSHRALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5804013 | 0.68 | SMN1; SMN2 (0.62) | POLBTSHRALDH1A1HTTMAPT | |
| SCHEMBL1063418 | 0.68 | NPSR1 (0.71) | POLBTSHRALDH1A1HTTMAPT | |
| SCHEMBL1431346 | 0.68 | NPC1 (0.62) | POLBTSHRALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525199-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS | Argenta Discovery Limited (GB) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004013130-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS AS HISTONE DEACETYLASE INHIBITORS | ARGENTA DISCOVERY LIMITED (GB) | 2004-02-12 | — | — | WO | disclosed |