Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | F7 | P08709 | 1/20 | 0.50 |
| ▸ | CBFB | Q13951 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14601535 | 0.87 | AMY1A (0.51) | AMY1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2324234 | 0.84 | NPC1 (0.62) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2310193 | 0.83 | RAB9A (0.44) | AMY1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL7136331 | 0.81 | NPC1 (0.51) | NPC1RAB9AALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL6282502 | 0.81 | GAA (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2310794 | 0.81 | NPC1 (0.46) | AMY1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2310791 | 0.81 | NPC1 (0.46) | AMY1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL5579984 | 0.80 | CHEK1 (0.59) | AMY1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2311266 | 0.80 | HSP90AB1 (0.41) | AMY1ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2311273 | 0.80 | HSP90AB1 (0.41) | AMY1ANPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482373-B2 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-20070027200-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2007-02-01 | — | — | US | disclosed |
| US-7132439-B2 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| US-20040029925-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | ICAGEN, INC. (US) | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027200-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | KCNJ2, KCNA3, KCNB2 | AMY1A 4827/4885NPC1 1216/4885RAB9A 3054/4885 |
| US-20040029925-A1 | Bis-benzimidazoles and related compounds as potassium channel modulators | KCNJ2, KCNA3, KCNB2 | AMY1A 4827/4885NPC1 1216/4885RAB9A 3054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.