Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 8/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2257064 | 0.94 | MKNK1 (0.44) | MKNK1FYNPI4KBPDE10APIK3CA | |
| SCHEMBL627315 | 0.84 | MKNK1 (0.37) | MKNK1FYNVNN1NPY5R | |
| SCHEMBL627067 | 0.78 | KDM4E (0.46) | GRIN2BNPY5R | |
| SCHEMBL15324843 | 0.77 | MKNK1 (0.42) | MKNK1FYNPI4KBPDE10APIK3CA | |
| SCHEMBL628252 | 0.75 | MKNK1 (0.57) | MKNK1FYNVNN1PIM1 | |
| SCHEMBL628254 | 0.75 | MKNK1 (0.57) | MKNK1FYNVNN1PIM1 | |
| SCHEMBL1944318 | 0.74 | MKNK1 (0.45) | MKNK1FYN | |
| SCHEMBL1944253 | 0.72 | TP53 (0.53) | MKNK1FYN | |
| SCHEMBL1945276 | 0.72 | MAPT (0.45) | MKNK1FYN | |
| SCHEMBL627611 | 0.72 | MAP3K12 (0.43) | FYNPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |