Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 16/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.39 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.39 |
| ▸ | MAP3K10 | Q02779 | 1/20 | 0.39 |
| ▸ | DMPK | Q09013 | 1/20 | 0.39 |
| ▸ | EPHA7 | Q15375 | 1/20 | 0.39 |
| ▸ | DLK1 | P80370 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626702 | 0.89 | MAP3K12 (0.43) | MAP3K12PIK3CAF2RL3MAP3K13NTRK1 | |
| SCHEMBL625673 | 0.89 | MAP3K12 (0.48) | MAP3K12PIK3CAF2RL3DLK1 | |
| SCHEMBL627440 | 0.86 | FYN (0.45) | MAP3K12PIK3CAFYNDLK1 | |
| SCHEMBL626582 | 0.84 | PIK3CA (0.42) | MAP3K12PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL624985 | 0.84 | KDM4E (0.40) | MAP3K12PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL627612 | 0.84 | FYN (0.56) | PIK3CAFYN | |
| SCHEMBL627610 | 0.84 | FYN (0.56) | PIK3CAFYN | |
| SCHEMBL12474086 | 0.81 | PIK3CA (0.47) | MAP3K12PIK3CAF2RL3PIK3CDPIK3CB | |
| SCHEMBL626269 | 0.81 | F2RL3 (0.44) | MAP3K12PIK3CAF2RL3PIK3CDPIK3CB | |
| SCHEMBL626145 | 0.79 | F2RL3 (0.43) | MAP3K12PIK3CAF2RL3PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |