Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6286208 | 0.87 | HTT (0.42) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL13567880 | 0.85 | HTR2C (0.53) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL1509090 | 0.85 | HTR2C (0.53) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL9546475 | 0.81 | SMN1; SMN2 (0.52) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL9546482 | 0.81 | SMN1; SMN2 (0.52) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL1508927 | 0.80 | SMN1; SMN2 (0.51) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL11109029 | 0.79 | HTR2C (0.52) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL11104947 | 0.79 | HTR2C (0.52) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL11104941 | 0.79 | HTR2C (0.52) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 | |
| SCHEMBL1508494 | 0.77 | HTR2C (0.51) | HTR2CSMN1; SMN2NPC1RAB9AAGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900238-B1 | HIV protease inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-05-31 | — | — | US | disclosed |
| EP-0873519-A4 | HIV PROTEASE INHIBITORS | SCRIPPS RESEARCH INST (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-0873519-A1 | HIV PROTEASE INHIBITORS | The Scripps Research Institute (US) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997021100-A9 | HIV PROTEASE INHIBITORS | — | 1997-10-30 | — | — | WO | disclosed |
| WO-1997021100-A1 | HIV PROTEASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1997-06-12 | — | — | WO | disclosed |