Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503644 | 0.88 | AKR1C3 (0.38) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL5249412 | 0.88 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAMAPTGAASETD7 | |
| SCHEMBL5249416 | 0.88 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAMAPTGAASETD7 | |
| SCHEMBL6286068 | 0.85 | KDM4E (0.39) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL5247154 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL6492444 | 0.81 | SMN1; SMN2 (0.37) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL5247115 | 0.81 | PTPN1 (0.41) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL5247119 | 0.81 | PTPN1 (0.41) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL6760466 | 0.80 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL6760468 | 0.80 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAMAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6891044-B2 | Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |