Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | DDX3X | O00571 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6282634 | 0.85 | SMN1; SMN2 (0.38) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL5247115 | 0.82 | PTPN1 (0.41) | KDM4ENPC1RAB9AMTORVCP | |
| SCHEMBL5247119 | 0.82 | PTPN1 (0.41) | KDM4ENPC1RAB9AMTORVCP | |
| SCHEMBL6492444 | 0.82 | SMN1; SMN2 (0.37) | NPC1RAB9AMTORVCPMAPT | |
| SCHEMBL6760466 | 0.80 | SMN1; SMN2 (0.38) | NPC1RAB9AMTORVCPMAPT | |
| SCHEMBL6760468 | 0.80 | SMN1; SMN2 (0.38) | NPC1RAB9AMTORVCPMAPT | |
| SCHEMBL5249416 | 0.79 | SMN1; SMN2 (0.39) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL5249412 | 0.79 | SMN1; SMN2 (0.39) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL5247160 | 0.79 | KDR (0.45) | NPC1RAB9AMAPTSMN1; SMN2PTPN1 | |
| SCHEMBL5247154 | 0.77 | SMN1; SMN2 (0.43) | MAPTSMN1; SMN2KMT2AMEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6891044-B2 | Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |