Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6760468 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL5247119 | 0.90 | PTPN1 (0.41) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL5247115 | 0.90 | PTPN1 (0.41) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL5249412 | 0.88 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL5249416 | 0.88 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL5247160 | 0.87 | KDR (0.45) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL5247154 | 0.85 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL6286068 | 0.80 | KDM4E (0.39) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL6282634 | 0.80 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL6492444 | 0.80 | SMN1; SMN2 (0.37) | SMN1; SMN2LMNAMAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040171634-A1 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, LLC | 2004-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171634-A1 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | CDK3, BRAF, ROCK1 | SMN1; SMN2 4854/4885LMNA 3648/4885MAPT 812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.