Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ALDH3A1 | P30838 | 5/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | ALDH2 | P05091 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9384529 | 0.83 | DRD2 (0.74) | DRD2DRD4ALDH1A1ALDH3A1ALDH2 | |
| SCHEMBL9096191 | 0.82 | DRD2 (0.62) | DRD2DRD4ALDH1A1TP53ALDH3A1 | |
| SCHEMBL6285415 | 0.82 | DRD2 (0.62) | DRD2DRD4ALDH1A1TP53ALDH3A1 | |
| Hydrochloric Acid SCHEMBL9096836 | 0.82 | DRD2 (0.72) | DRD2DRD4ALDH1A1ALDH3A1ALDH2 | |
| SCHEMBL9097463 | 0.82 | PARK7 (0.67) | DRD2DRD4ALDH1A1TP53ALDH3A1 | |
| SCHEMBL9095875 | 0.81 | DRD2 (0.83) | DRD2DRD4ALDH1A1TP53ALDH3A1 | |
| Hydrochloric Acid SCHEMBL9096767 | 0.81 | DRD2 (0.61) | DRD2DRD4ALDH1A1TP53ALDH3A1 | |
| Hydrochloric Acid SCHEMBL9094768 | 0.81 | DRD2 (0.61) | DRD2DRD4ALDH1A1TP53ALDH3A1 | |
| SCHEMBL9096863 | 0.81 | DRD2 (0.64) | DRD2DRD4ALDH1A1TP53ALDH3A1 | |
| SCHEMBL9096146 | 0.81 | DRD2 (0.55) | DRD2DRD4ALDH1A1TP53ALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906090-B1 | Compositions and methods for treating mycobacterial diseases | ASTRAZENECA AB (SE) | 2005-06-14 | — | — | US | claimed |
| EP-1058548-B1 | THE USE OF ISATIN AND OXINDOLE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT FOR USE IN THE TREATMENT OF MYCOBACTERIAL DISEASE | ASTRAZENECA AB (SE) | 2003-09-17 | — | — | EP | claimed |
| US-6906090-B1 | Compositions and methods for treating mycobacterial diseases | ASTRAZENECA AB (SE) | 2005-06-14 | — | — | US | disclosed |
| EP-1058548-B1 | THE USE OF ISATIN AND OXINDOLE DERIVATIVES IN THE PREPARATION OF A MEDICAMENT FOR USE IN THE TREATMENT OF MYCOBACTERIAL DISEASE | ASTRAZENECA AB (SE) | 2003-09-17 | — | — | EP | disclosed |