Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ACMSD | Q8TDX5 | 4/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.44 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.44 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.44 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23090388 | 0.98 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL21682098 | 0.96 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL818480 | 0.86 | ALDH1A1 (0.59) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL819768 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL11316463 | 0.81 | ALDH1A1 (0.52) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL4041645 | 0.81 | HTT (0.47) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL23090413 | 0.79 | KDM4E (0.50) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL4260001 | 0.77 | HSD17B10 (0.41) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL3895440 | 0.77 | HTT (0.47) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL4016463 | 0.77 | ALDH1A1 (0.52) | ALDH1A1KDM4EHSD17B10HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849705-B2 | Bifunctional polyaddition compounds as crosslinkers for polyurethane powder coatings | DEGUSSA AG (DE) | 2005-02-01 | — | — | US | claimed |
| US-20030212239-A1 | Bifunctional polyaddition compounds as crosslinkers for polyurethane powder coatings | DEGUSSA AG (DE) | 2003-11-13 | — | — | US | claimed |
| US-5143809-A | Polyesters from bisphenol type diol, dicarboxylic acid and tricarboxylic acid | KONICA CORPORATION (JP) | 1992-09-01 | — | — | US | claimed |
| US-9290467-B2 | Cyclic amides | Hoffmann—La Roche Inc. (US) | 2016-03-22 | — | — | US | disclosed |
| EP-2802591-B1 | MACROCYCLIC AMIDES AS PROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2016-03-16 | — | — | EP | disclosed |
| US-8901337-B2 | Metal complexes having dual histone deacetylase inhibitory and DNA-binding activity | ROYAL COLLEGE OF SURGEONS IN IRELAND (IE) | 2014-12-02 | — | — | US | disclosed |
| EP-2802591-A1 | MACROCYCLIC AMIDES AS PROTEASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-11-19 | — | — | EP | disclosed |
| US-20130196965-A1 | CYCLIC AMIDES | HOFFMANN-LA ROCHE INC. (US) | 2013-08-01 | — | — | US | disclosed |
| WO-2013104613-A1 | MACROCYCLIC AMIDES AS PROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-07-18 | — | — | WO | disclosed |
| US-20120190874-A1 | METAL COMPLEXES HAVING DUAL HISTONE DEACETYLASE INHIBITORY AND DNA-BINDING ACTIVITY | ROYAL COLLEGE OF SURGEONS IN IRELAND (IE) | 2012-07-26 | — | — | US | disclosed |
| US-6849705-B2 | Bifunctional polyaddition compounds as crosslinkers for polyurethane powder coatings | DEGUSSA AG (DE) | 2005-02-01 | — | — | US | disclosed |
| US-4006127-A | Cationic diazacyanine dyestuffs | BAYER AKTIENGESELLSCHAFT (DT) | 1977-02-01 | — | — | US | disclosed |
| US-4000130-A | INDOLE DYES, POLYACRYLONITRILE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-12-28 | — | — | US | disclosed |
| US-4000141-A | SUBSTITUTED TETRAHYDRO QUINOLINE CATIONIC DYESTUFFS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-12-28 | — | — | US | disclosed |
| US-3992405-A | ESPECIALLY FOR DYEING POLYACRYLIC FIBERS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-11-16 | — | — | US | disclosed |
| US-3991042-A | Basic azo dyestuffs containing a benzthiazole and a tetrahydroquinoline nucleus | BAYER AKTIENGESELLSCHAFT (DT) | 1976-11-09 | — | — | US | disclosed |
| US-3971807-A | BENZINDOLE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-07-27 | — | — | US | disclosed |
| US-3959310-A | BENZINDOLE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-25 | — | — | US | disclosed |
| US-3956264-A | Basic azo dyestuffs having indolyl-methyleneamino substituent in the diazo component | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-11 | — | — | US | disclosed |
| US-3948877-A | POLYACRYLONITRILE, ACID MODIFIED POLYESTERS OR POLYAMIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130196965-A1 | CYCLIC AMIDES | CCND2, CCKBR, CCNB1 | ALDH1A1 565/4885KDM4E 2983/4885HSD17B10 1790/4885 |
| US-20120190874-A1 | METAL COMPLEXES HAVING DUAL HISTONE DEACETYLASE INHIBITORY AND DNA-BINDING ACTIVITY | HDAC1, HDAC9, HDAC2 | ALDH1A1 3911/4885KDM4E 255/4885HSD17B10 1801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.