Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 7/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 7/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6283027 | 0.86 | MAPK14 (0.50) | MAPK14ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL6283253 | 0.86 | MAPK14 (0.53) | MAPK14ALDH1A1PTGS2KDM4EHPGD | |
| SCHEMBL6501754 | 0.84 | MAPK14 (0.50) | MAPK14ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL6280814 | 0.83 | MAPK14 (0.55) | MAPK14ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL6285603 | 0.83 | MAPK14 (0.50) | MAPK14ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL6276678 | 0.81 | PTGS2 (0.62) | MAPK14PTGS2RAB9AKDM4E | |
| SCHEMBL6286370 | 0.81 | MEN1 (0.50) | MAPK14ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL6505328 | 0.80 | MAPK14 (0.51) | MAPK14ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL6503440 | 0.80 | MAPK14 (0.76) | MAPK14PTGS2 | |
| SCHEMBL6282401 | 0.75 | ALDH1A1 (0.76) | MAPK14ALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | claimed |
| US-6962933-B1 | Method for inhibiting p38 MAP kinase or TNF-α production using a 1,3-thiazole | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-08 | — | — | US | disclosed |
| EP-1205478-A1 | p38MAP KINASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 2002-05-15 | — | — | EP | disclosed |