Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 10/20 | 0.59 |
| ▸ | MEN1 | O00255 | 8/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 6/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520353 | 0.94 | GLA (0.60) | GLALTC4SMAPTMEN1KMT2A | |
| SCHEMBL1520127 | 0.89 | GLA (0.68) | GLALTC4SMAPTMEN1KMT2A | |
| SCHEMBL28684233 | 0.82 | GLA (0.61) | GLAMAPTMEN1KMT2ALMNA | |
| SCHEMBL29353571 | 0.81 | RAB9A (0.55) | GLAMEN1KMT2AALOX12LMNA | |
| SCHEMBL6957663 | 0.81 | RAB9A (0.55) | GLAMEN1KMT2AALOX12LMNA | |
| SCHEMBL6963810 | 0.81 | NPC1 (0.52) | MAPTMEN1KMT2ALMNAGAA | |
| SCHEMBL1520080 | 0.80 | IDO1 (0.55) | GLAMAPTMEN1KMT2AALOX12 | |
| SCHEMBL1520004 | 0.78 | MEN1 (0.81) | LTC4SMAPTMEN1KMT2AALOX12 | |
| SCHEMBL6961594 | 0.78 | RAB9A (0.54) | MAPTMEN1KMT2AALOX12LMNA | |
| SCHEMBL6953553 | 0.78 | NPC1 (0.54) | MAPTMEN1KMT2ALMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960606-B2 | Adamantyl Thiazole Thioureas | PARKER HUGHES INSTITUTE (US) | 2005-11-01 | — | — | US | disclosed |
| US-20030207921-A1 | Aromatic and heterocyclic thiazolyl thiourea compounds and use | PARKER HUGHES INSTITUTE (US) | 2003-11-06 | — | — | US | disclosed |
| EP-1326852-A1 | AROMATIC AND HETEROCYCLIC THIAZOLYL THIOUREA COMPOUNDS AND USE | Parker Hughes Institute (US) | 2003-07-16 | — | — | EP | disclosed |
| EP-0540143-B1 | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 2003-02-05 | — | — | EP | disclosed |
| WO-2002032889-A1 | AROMATIC AND HETEROCYCLIC THIAZOLYL THIOUREA COMPOUNDS AND USE | PARKER HUGHES INSTITUTE (US) | 2002-04-25 | — | — | WO | disclosed |
| US-5714503-A | Compounds and methods for inhibition of HIV and related viruses | MEDIVIR AB (SE) | 1998-02-03 | — | — | US | disclosed |
| US-5658907-A | THIOUREA VIRICIDES | MEDIVIR A/B (SE) | 1997-08-19 | — | — | US | disclosed |
| US-5593993-A | VIRICIDES FOR HTLV TREATMENT OF AIDS | MEDIVIR AB (SE) | 1997-01-14 | — | — | US | disclosed |
| EP-0540143-A2 | Compounds and methods for inhibition of HIV and related viruses | Medivir Aktiebolag (SE) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993003022-A1 | COMPOUNDS AND METHODS FOR INHIBITION OF HIV AND RELATED VIRUSES | MEDIVIR AB (SE) | 1993-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207921-A1 | Aromatic and heterocyclic thiazolyl thiourea compounds and use | TYMP, PNP, TPMT | GLA 4277/4885LTC4S 2471/4885MAPT 1006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.