Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6283634 | 0.82 | RET (0.35) | NPC1RET | |
| SCHEMBL6283631 | 0.82 | RET (0.35) | NPC1RET | |
| SCHEMBL5250924 | 0.81 | ENPP2 (0.33) | NPC1 | |
| SCHEMBL5249938 | 0.73 | NFE2L2 (0.37) | NPC1 | |
| SCHEMBL5249942 | 0.73 | NFE2L2 (0.37) | NPC1 | |
| SCHEMBL5512063 | 0.73 | NPC1 (0.36) | NPC1 | |
| SCHEMBL7511036 | 0.73 | NPC1 (0.36) | NPC1 | |
| SCHEMBL6282051 | 0.72 | KDR (0.34) | NPC1 | |
| SCHEMBL6282047 | 0.72 | KDR (0.34) | NPC1 | |
| SCHEMBL5526396 | 0.72 | CHEK1 (0.39) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6891044-B2 | Indazole compounds and pharmaceutical compositions for Inhibiting protein kinases, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-05-10 | — | — | US | disclosed |