Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 18/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.34 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6284709 | 0.93 | CHEK2 (0.38) | CHEK2CHEK1 | |
| SCHEMBL5953146 | 0.86 | HPSE (0.45) | CHEK2 | |
| SCHEMBL7049004 | 0.81 | CHEK2 (0.43) | CHEK2CHEK1 | |
| SCHEMBL6283839 | 0.81 | CHEK2 (0.43) | CHEK2CHEK1 | |
| SCHEMBL13375229 | 0.79 | CBFB (0.37) | CHEK2 | |
| SCHEMBL6695582 | 0.76 | PARP1 (0.45) | CHEK2CHEK1 | |
| SCHEMBL5952106 | 0.75 | NPC1 (0.46) | PKN1PKN2 | |
| SCHEMBL5952307 | 0.74 | FABP6 (0.38) | — | |
| SCHEMBL5952225 | 0.74 | KDM4E (0.39) | — | |
| SCHEMBL5952676 | 0.74 | HPSE (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897208-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | disclosed |