Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5951708 | 0.82 | NPBWR1 (0.45) | NPBWR1FLT3PDPK1DGAT1KCNH2 | |
| SCHEMBL5951733 | 0.79 | CHEK1 (0.39) | NPBWR1FLT3PDPK1DGAT1KCNH2 | |
| SCHEMBL13374038 | 0.79 | DYRK1A (0.44) | NPBWR1FLT3PDPK1DGAT1KCNH2 | |
| SCHEMBL5952391 | 0.78 | ALDH1A1 (0.41) | NPBWR1FLT3PDPK1DGAT1KCNH2 | |
| SCHEMBL5951462 | 0.78 | KIF11 (0.43) | NPBWR1PDPK1DGAT1KCNH2SOAT1 | |
| SCHEMBL5953146 | 0.77 | HPSE (0.45) | CHEK2 | |
| SCHEMBL4469806 | 0.76 | PARP1 (0.52) | PARP1CHEK2NPBWR1DGAT1KCNH2 | |
| SCHEMBL6283906 | 0.76 | CHEK2 (0.40) | CHEK2CHEK1 | |
| SCHEMBL19994513 | 0.76 | CHEK2 (0.65) | PARP1CHEK2MAP2K4NPBWR1DGAT1 | |
| SCHEMBL13374039 | 0.76 | PDPK1 (0.46) | PDPK1DGAT1KCNH2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441725-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Aventis Pharmaceuticals Inc. (US) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003035065-A1 | BENZIMIDAZOLES AND ANALOGUES AND THEIR USE AS PROTEIN KINASES INHIBITORS | AVENTIS PHARMACEUTICALS INC (US) | 2003-05-01 | — | — | WO | disclosed |